Study of Anthocyanin Molecule Blocking as Anti-Hypertensive through the Pathway of the Renin-Angiotensin-Aldosterone System (RAAS)

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چکیده

Anthocyanins are flavonoid-derived compounds that can reduce blood pressure. This study aims to determine the affinity value of compound bind Angiotensin Converting Enzyme (ACE) and II type 1 Receptor (AT1R) distance shape bond occurs. The results anthocyanin-derived Delphinidin, Petunidin, Malvidin, Cyanidin, Peonidin, Pelargonidin have anti-hypertensive potential through Renin Aldosterone (RAAS) pathway based on molecular docking calculations. each, against -7.7; -7.8; -7.8, -7.7, best in is shown Malvidin test which has three types hydrogen bonds at a ± 2 Å (ASP377, TYR520, ASP415) same as lisinopril control (TYR520). While -7.6, respectively, ligand -7.8 kcal/mol four (TYR92, SER105, ARG167, TRP84) one kind common with

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ژورنال

عنوان ژورنال: Indonesian Journal of Chemical Science

سال: 2023

ISSN: ['2614-2627', '2338-5359', '2502-6844']

DOI: https://doi.org/10.30598//ijcr.2023.11-bud